Author's response to reviews Title: Safety and survival effect comparision of adjuvant tamoxifen and toremifene in premenopausal patients with ER/PR positive breast cancer: a retrospective cohort study Authors:
نویسندگان
چکیده
Fengxi Su Prof ([email protected]) Ran Gu Dr ([email protected]) Weijuan Jia M.D. ([email protected]) Yunjie Zeng Dr ([email protected]) Nanyan Rao Prof ([email protected]) Yue Hu Dr ([email protected]) Shunrong Li Dr ([email protected]) Jiannan Wu Dr ([email protected]) Liang Jin Dr ([email protected]) Lijuan Chen ([email protected]) Erwei Song Prof ([email protected]) Meijun Long Dr ([email protected]) Kai Chen Dr ([email protected]) Qiaozhen Xiao ([email protected]) Mei Wu ([email protected]) Lili Chen ([email protected])
منابع مشابه
High progesterone receptor expression correlates to the effect of adjuvant tamoxifen in premenopausal breast cancer patients.
PURPOSE Tamoxifen has long been the drug of choice in adjuvant endocrine therapy of steroid hormone receptor-positive breast cancer, and it still remains important due to its well-documented beneficial effect. Hormone receptor status is often reported as "positive" or "negative" using 10% positive nuclei as a cutoff. In this study, we aimed to assess whether a further subclassification of hormo...
متن کاملOriginal article Toremifene and tamoxifen are equally effective for early-stage breast cancer: first results of International Breast Cancer Study
Background: Toremifene is a chlorinated derivative of tamoxifen, developed to improve its risk– benefit profile. The International Breast Cancer Study Group (IBCSG) conducted two complementary randomized trials for periand postmenopausal patients with node-positive breast cancer to compare toremifene versus tamoxifen as the endocrine agent and simultaneously investigate a chemotherapy-oriented ...
متن کاملSurvival Benefit of Tamoxifen in Estrogen Receptor-Negative and Progesterone Receptor-Positive Low Grade Breast Cancer Patients
PURPOSE This study aimed to analyze the efficacy and prognostic significance of adjuvant tamoxifen in breast cancer patients with various hormone receptor statuses. METHODS Typically, 1,260 female breast cancer patients were recruited in this study. The correlation between estrogen receptor (ER)/progesterone receptor (PR) phenotypes and clinical characteristics was investigated, and the survi...
متن کاملبررسی هیستوپاتولوژی و مارکرهای بیولوژی در زنان مبتلا به سرطان پستان قبل از یائسگی (زیر 40 سال) و پس از یائسگی (بالای 60 سال) در بیمارستان رسول اکرم(ص) و آتیه
Background & Aim: Breast carcinoma is the most common malignant tumor and the leading cause of carcinoma death in women.One of the factors which have been proposed in prognosis and treatment of breast carcinoma is hormonal status and hormonal receptors. In this study, we investigated histopathology(prognostic factors) and biologic markers(estrogen receptor ER, progesterone receptor PR, P53...
متن کاملErythropoietin receptor expression and correlation to tamoxifen response and prognosis in breast cancer.
PURPOSE The main function of erythropoietin (EPO) is to stimulate erythropoiesis. EPO receptors (EPOR) are expressed in other cell types, including tumor cells, suggesting that the EPO/EPOR pathway governs additional cellular processes besides erythropoiesis. Recombinant EPO (rhEPO) is frequently given to anemic cancer patients, although data on clinical outcome are conflicting. In an attempt t...
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تاریخ انتشار 2011